Buy GeroNova's
Bio-Enhanced® R-Lipoic Acid, K-RALA™ 100 mg vegcaps
K-RALA™
(Bio-Enhanced® R-Lipoic Acid)
Unsurpassed Stability, Absorption & Bioavailability
BioEnhanced® R-Lipoic Acid products from GeroNova Research are superior to other pure, unstabilized RLA products.
Why Take Bio-Enhanced® R-lipoic Acid?
- Bio-Enhanced® R-Lipoic Acid (as Na-RALA) is heat and shelf stable, highly soluble and has proven to be the most bioavailable oral form of lipoic acid on the market.
- Bio-Enhanced® RLA is significantly more bio-available than the ‘free-acid’ form of R-Lipoic Acid (RLA). In a preliminary human pharmacokinetic trial, the maximum plasma concentration was 40 times higher than that of unstabilized RLA.
- Bio-Enhanced® RLA is made by a proprietary process which removes all traces of residual solvents, a significant problem in unstabilized RLA products.
- Bio-Enhanced® RLA does not cause heartburn, indigestion or stomach discomfort, which can occur with unstabilized RLA.
- Bio-Enhanced® R-Lipoic Acid is a quick release product, attaining high plasma levels rapidly.
- Bio-Enhanced® R-Lipoic Acid is much more stable than RLA even at elevated temperatures. Heated to over 150° C for 6 hours there is no loss of activity, and polymer formation was undetectable. Pure RLA would instantaneously polymerize under these conditions.
- Bio-Enhanced® R-Lipoic Acid requires no refrigeration and does not polymerize, whereas RLA polymerizes at temperatures slightly above ambient. The polymerization of RLA is accelerated by light, heat and moisture.
Bio-Enhanced® R-Lipoic Acid can be complemented by any of our softgel R-PLUS products, which sustain detectable levels of RLA in the plasma for up to 4 days.
Note: The R-Lipoic Acid in BioEnhanced® R-Lipoic Acid is stabilized with Na (sodium). However, one serving contains less than 1% of the Daily Value for sodium, an insignificant contribution to dietary sources. The sodium in this product is unlikely to affect blood pressure levels.
Serving Size: 1 capsule
Product Contains: BioEnhanced® R-Lipoic Acid (as Na RALA), 100 mg or 300 mg, Sodium Bicarbonate
Other Ingredients: Vegetarian magnesium stearate, vegetarian capsule
Recommended Use: Take one or more capsules per day with meals, or as directed by your health care provider.
100 mg/90vegcaps
300 mg/60 vegcaps
ABSORPTION and BIOAVAILABILITY
ABSORPTION is the movement of R-lipoic acid into the bloodstream. It involves several phases: ingestion by mouth, dissolution (the breakdown of single crystals into single molecules) in the stomach and small intestine into the absorption cells which deliver R-lipoic acid into the lymphatics, and then into the general circulation of the blood where RLA becomes bioavailable. Without absorption, RLA cannot be bioavailable.
BIOAVAILABILITY refers to the amount (or percent of dose) of RLA that reaches the systemic blood circulation and is therefore available for use by the cells. Bioavailability is dependent upon absorption. In pharmacology, the absolute bioavailability of RLA measures the availability of RLA in the systemic ciculation. This is determined by obtaining a blood plasma concentration over time, referred to as the AUC (area under the curve). Relative bioavailability compares the bioavailability of one product to another. In a preliminary human clinical trial, the AUC for GeroNova's Bio-Enhanced® R-Lipoic Acid was 40 times higher than that of unstabilized RLA.
There are wide variations in the R/S ratios and total polymer contents of raw material and finished products now on the market. Few supplement companies have experience with RLA and are unaware of the myriad of problems associated with its encapsulation and stability. GeroNova's Bio-Enhanced®, Stabilized R-Lipoic Acid caps are made from the only stable and highly bioavailable form of R-Lipoic Acid available.