In-House Research & Collaborations
GeroNova Research is setting the industry standards for research, analysis and lipoic acid products for the health conscious consumer.
GeroNova Publications
A validated, normal phase HPLC method for the analysis of lipoic acid enantiomers. Carlson DA & Smith AR. June 6, 2008.
The validated method here may be used by any individual, academic institution, or analytical laboratory as long as credit is given to the authors & GeroNova Research Inc. as the source of the method. We are offering this method to the industry in order to educate testing laboratories in the analysis of RLA containing products.To date, this is the fastest and most reproducible method available for the analysis of the enantiomers of lipoic acid. Download the method here.
An evaluation of the stability and plasma pharmacokinetics of R-lipoic acid (RLA) and R-dihydrolipoic acid (R-DHLA) dosage forms in human plasma from healthy volunteers. Carlson DA, Young KL, Fischer SJ, Ulrich H. Chapter 10 in: Packer L, Patel M, eds. Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. London, England: Taylor & Francis Publishers; 2008:235-270.
Buy the (hardcover) book at our online store.
View the contents of the book chapter
The Plasma Pharmacokinetics of R-(+)-Lipoic Acid Administered as Sodium R-(+)-Lipoate to Healthy Human Subjects. Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L. Altern Med Rev 2007;12(4) 343-351.
Read the abstract (full article in pdf can also be downloaded) on the Pub Med website
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A comparison of the pharmacokinetic profiles of lipoate enantiomers with the racemic mixture in healthy human subjects indicates possible stereoselective gut transport. Carlson DA, Smith AR, Fischer SJ, Young KL.
View the poster from OCC Santa Barbara, CA March 12-15, 2008
Further characterization of the lipoic acid enantiomers provide new research opportunities. Stereochemistry, Pharmacokinetics & Metabolism:Toward a Comprehensive Mechanism of Action. Oxygen Club of California PowerPoint presentation by David A.Carlson, March,15, 2008.
Download the PowerPoint presentation
Download the references
Lipoic Acid stereochemistry references:
1-alphabetical by 1st author, 2-chronological.
View alphabetical references
View chronological references
Please notify us of any additional lipoic acid stereochemistry references (abstracts, papers, posters, book chapters, conference presentations, unpublished studies, published in vitro or in vivo studies, but not patents), we might have missed so we can keep the list comprehensive and up to date.
Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.
Maczurek A (b,c), Hager K (a), Kenlies M (a), Sharman M (d), Martins R (a), Engel J (e), Carlson DA (f), Münch G (b,c). accepted for publication (2008) Advanced Drug Delivery Reviews.
a. Klinik für Medizinische Rehabilitation und Geriatrie der Henriettenstiftung, Hannover, Germany
b. Dept. of Pharmacology, School of Medicine, University of Western Sydney, Australia
c. Dept. of Biochemistry and Molecular Biology, James Cook University, Townsville
d. Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Australia
e. Zentaris GmbH, Frankfurt am Main, Germany
f. GeroNova Research, Inc., Richmond, CA, USA
Lipoic acid in Alzheimer's disease - From basic therapeutic concepts to clinical trials.
Marlies Kenklies, Klaus Hager, Gerald Muench, Shanmugam Kirubakaran, Annette Maczurek, Grant Stuchbury, David Carlson
Download the abstract from the OCC conference, March 2008
The case against controlled release lipoic acid: A pharmacokinetic-mechanistic argument (part 1)
Read the paper
David A Carlson; CV
Anthony R Smith, Ph.D; CV
Heinz Ulrich, M.D.; CV
The Plasma Pharmacokinetics of R-lipoic Acid Metabolites & the Possible contributions to the overall mechanisms of action of Lipoic acid in Human Volunteers. Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L; Study in progress.
A Comprehensive Review of the Animal & Human Pharmacokinetics of Lipoic Acid Carlson DA, Ulrich H.( 2008), manuscript in preparation.
The Pharmacokinetics and Pharmacodynamics of R-(+)-alpha lipoic acid. Krone D; Ph.D. Thesis, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (2002). English translation by Annette Maczurek, and Heinz Ulrich, M.D. edited by David A. Carlson (2007)
In Vitro Metabolism of a-Lipoic Acid Especially Taking Enantioselective Biotransformation into Account. Lang G; Ph.D. Thesis, University of Münster, Münster, Germany (1992). English Translation: Annette Maczurek, edited by David A. Carlson (2008)
Lipoic Acid: From the Bench Top to the Reactor; A comprehensive review and practical guide to the laboratory and industrial-scale synthesis of lipoic acid, metabolites and analogs. Carlson DA.
This book is based on practical laboratory work of the author and his staff between 1998 and 2008 and is written in the format of the Organic Synthesis series. This monumental work outlines every published synthesis and patent concerning LA and DHLA (and metabolites) with reaction sequences, physical properties, spectral data and lab notes on each of the intermediates and analogs. Special emphasis is on the production of green and cost effective chiral intermediates, resolution strategies and racemizations for production of the single enantiomers. Projected release: winter 2009.
Read the book summary
A chronological listing of Lipoic Acid conferences.
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Please contact us if you know of other Lipoic Acid conferences not listed.