Research Overview
GeroNova Research is setting the industry standards for research, analysis and lipoic acid products.
GeroNova Publications
Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.
Maczurek A (b,c), Hager K (a), Kenlies M (a), Sharman M (d), Martins R (a), Engel J (e), Carlson DA (f), Münch G (b,c). Advanced Drug Delivery Reviews (2008).
Read the abstract on the Pub Med website.A validated, normal phase HPLC method for the analysis of lipoic acid enantiomers. Carlson DA & Smith AR. June 6, 2008.
The validated method here may be used by any individual, academic institution, or analytical laboratory as long as credit is given to the authors & GeroNova Research Inc. as the source of the method. We are offering this method to the industry in order to educate testing laboratories in the analysis of R-Lipoic Acid containing products.To date, this is the fastest and most reproducible method available for the analysis of the enantiomers of lipoic acid.
Download the method here.An Evaluation of the Stability and Pharmacokinetics of R-lipoic Acid and R-Dihydrolipoic Acid Dosage Forms in Plasma from Healthy Human Subjects
Carlson DA, Young KL, Fischer SJ, Ulrich H. Chapter 10 in: Packer L, Patel M, eds. Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. London, England: Taylor & Francis Publishers; 2008:235-270.
Buy the (hardcover) book at our online store.
The Plasma Pharmacokinetics of R-(+)-Lipoic Acid Administered as Sodium R-(+)-Lipoate to Healthy Human Subjects.
Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L. Altern Med Rev 2007;12(4) 343-351
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View the posterThis paper has been cited in the following articles; View pdf
A comparison of the pharmacokinetic profiles of lipoate enantiomers with the racemic mixture in healthy human subjects indicates possible stereoselective gut transport.
Carlson DA, Smith AR, Fischer SJ, Young KL.
View the poster from OCC Santa Barbara, CA March 12-15, 2008Further characterization of the lipoic acid enantiomers provide new research opportunities. Stereochemistry, Pharmacokinetics & Metabolism:Toward a Comprehensive Mechanism of Action.
Oxygen Club of California PowerPoint presentation by David A.Carlson, March,15, 2008.
Download the PowerPoint presentation
Download the referencesLipoic Acid stereochemistry references: 1-alphabetical by 1st author, 2-chronological.
View alphabetical references (updated 4/07/09)
View chronological references (updated 4/07/09)Our primary interest in the areas of basic lipoic acid (LA) research as well as the nutraceutical and clinical applications of LA is the differentiation of racemic (+/-)-lipoic acid from the individual enantiomers, R-Lipoic Acid and SLA.
Despite the ever increasing number of papers on the pharmacology and molecular biology of lipoic acid, most studies have used only the racemic mixture. In order to facilitate future research we have compiled a comprehensive list of molecular biology and pharmacology references regarding some aspect of lipoic acid stereochemistry.
Please notify us of any additional lipoic acid stereochemistry references (abstracts, papers, posters, book chapters, conference presentations, unpublished studies, published in vitro or in vivo studies, but not patents) we might have missed so we can keep the list up to date. Patents will be reviewed in the upcoming book, "Lipoic Acid: From the Bench Top to the Reactor; A comprehensive review and practical guide to the laboratory and industrial-scale synthesis of lipoic acid, metabolites and analogs".
Lipoic acid in Alzheimer's disease - From basic therapeutic concepts to clinical trials.
Marlies Kenklies, Klaus Hager, Gerald Münch, Shanmugam Kirubakaran, Annette Maczurek, Grant Stuchbury, David Carlson
Download the abstract from the OCC conference, March 2008The case against controlled release lipoic acid: A pharmacokinetic-mechanistic argument (part 1)
Read the paper
David A Carlson; CV
Anthony R Smith, Ph.D; CV
Heinz Ulrich, M.D.; CVThe Plasma Pharmacokinetics of R-lipoic Acid Metabolites & the Possible contributions to the overall mechanisms of action of Lipoic acid in Human Volunteers.
Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L; Study in progress.
A Comprehensive Review of the Animal & Human Pharmacokinetics of Lipoic Acid
Carlson DA, Ulrich H.( 2008), manuscript in preparation.
The Pharmacokinetics and Pharmacodynamics of R-(+)-alpha lipoic acid.
Krone D; Ph.D. Thesis, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (2002). English translation by Annette Maczurek, and Heinz Ulrich, M.D. edited by David A. Carlson (2007)
In Vitro Metabolism of a-Lipoic Acid Especially Taking Enantioselective Biotransformation into Account.
Lang G; Ph.D. Thesis, University of Münster, Münster, Germany (1992). English Translation: Annette Maczurek, edited by David A. Carlson (2008)
Lipoic Acid: From the Bench Top to the Reactor; A comprehensive review and practical guide to the laboratory and industrial-scale synthesis of lipoic acid, metabolites and analogs. Carlson DA.
This book is based on practical laboratory work of the author and his staff between 1998 and 2008 and is written in the format of the Organic Synthesis series. This monumental work outlines every published synthesis and patent concerning LA and DHLA (and metabolites) with reaction sequences, physical properties, spectral data and lab notes on each of the intermediates and analogs. Special emphasis is on the production of green and cost effective chiral intermediates, resolution strategies and racemizations for production of the single enantiomers.
Read the book summaryA chronological listing of Lipoic Acid conferences.
Please contact us if you know of other Lipoic Acid conferences not listed.