R-Lipoic Acid Peer-Reviewed Research

Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis. J Neural Transm Suppl. 2007;(72):189-93.

Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R-alpha-lipoic acid. Cui X, Zuo P, Zhang Q, et al. J Neurosci Res. 2006 Mar 22;

Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy. Lin J, Bierhaus A, Bugert P, et al. Diabetologia. 2006 Mar 7;

L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties. Di Stefano A, Sozio P, Cocco A, et al. J Med Chem. 2006 Feb 23;49(4):1486-93.

Differential activity of lipoic Acid enantiomers in cell culture. Smith JR, Thiagaraj HV, Seaver B, et al. J Herb Pharmacother. 2005;5(3):43-54.

(R)-{alpha}-Lipoic Acid Protects Retinal Pigment Epithelial Cells from Oxidative Damage. Voloboueva LA, Liu J, Suh JH, Ames BN, Miller SS. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4302-10.

Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. Suh JH, Moreau R, Heath SH, Hagen TM. Redox Rep. 2005;10(1):52-60.

Delaying the mitochondrial decay of aging with acetylcarnitine. Ames BN, Liu J. Ann N Y Acad Sci. 2004 Nov;1033:108-16.

(r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia. Frolich L, Gotz ME, et al. J Neural Transm. 2004 Mar;111(3):295-310.

Effect of R(+)alpha-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes. Walgren JL, Amani Z, et al. Metabolism. 2004 Feb;53(2):165-73.

(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Suh JH, Wang H, Liu RM, Liu J, Hagen TM. Arch Biochem Biophys. 2004 Mar 1;423(1):126-35.

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.Suh JH, Shenvi SV, Hagen TM et al. Proc Natl Acad Sci U S A. 2004 Feb 25.

ALS/Lt: A New Type 2 Diabetes Mouse Model Associated With Low Free Radical Scavenging Potential. Mathews CE, Bagley R, Leiter EH. Diabetes. 2004;53 Suppl 1:S125-9.

Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid. Smith AR, Hagen TM. Biochem Soc Trans. 2003 Dec;31(Pt 6):1447-9.

Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism. De Arriba SG, Loske C, Meiners I, et al. Munch GJ Cereb Blood Flow Metab. 2003 Nov;23(11):1307-13.

Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers. Teichert J, Hermann R, Ruus P, Preiss R. J Clin Pharmacol. 2003 Nov;43(11):1257-67.

Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat. Teachey MK, Taylor ZC, Maier T, et al. Metabolism. 2003 Sep; 52(9):1167-74.

Exercise training and antioxidants: relief from oxidative stress and insulin resistance. Henriksen EJ, Saengsirisuwan V. Exerc Sport Sci Rev. 2003 Apr;31(2):79-84. 

Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. Bharat S, Cochran BC, Ames BN, et al. Neurotoxicology. 2002 Oct;23(4-5):479-86.

Inhibition of glucose production and stimulation of bile flow by R (+)-alpha-lipoic acid enantiomer in rat liver. Anderwald C, Koca G, et al. M.Liver. 2002 Aug;22(4):355-62. 

R-Alpha Lipoic Acid Action on Cell Redox Status, the Insulin Receptor, and Glucose Uptake in 3T3-L1 Adipocytes; Moini, H. Tirosh, O. Archives of Biochem & BioPhys 397, No2 384-391 (2002)

Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Liu, J. Killilea, D.W. et al. Proc Nat Acad Sci 99, 1876-1881 (2002)

Delaying Brain Mitochondrial Decay and Aging with Mitochondrial Antioxidants and metabolites. Liu, J., Atamna, H. et al. Ann NY Acad Sci 959:133-166 (2002)

Memory Loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-alpha lipoic acid. Liu, J, Head, E. et al. Proc Natl Acad Sci USA 99, 2356-2361 (2002)

Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Hagen, T.M. Liu, J. et al. Proc Nat Acad Sci USA vol 99, issue 4, 1870-1875 (2002)

Alpha lipoic acid as a new treatment option for Alzheimer type dementia. Hager, K, Marahrens, A. et al. Arch Geron Geriatr 32 (3): 275-282 (2001)

Oxidative Stress in the Aging Rat Heart is Reversed by Dietary Supplementation with (R)-Lipoic Acid. Hagen, T.M, Shigeno, E.T. et al. FASEB J. 15, 700-706(year 2001)

Increased mitochondrial decay and oxidative stress in the aging rat heart: improvement by dietary supplementation with (R)-lipoic acid. Hagen, T.M. In Free Radicals in Chemistry, Biology and Medicine 27, 262-271. (2000)

(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Hagen, T.M, Vinarsky, V. et al. Antiox. Redox Signaling 2, 473-483(year 2000)

(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. Hagen, T.M, Ingersoll, R.T. et al. FASEB J. 13, 411-418(year 1999)

Dose-proportionality of oral thiotic acid-coincidence of assessments via pooled plasma and individual data. Breithaupt-Grogler K, Niebch G, et al. Eur J Pharm Sci. 1999 Apr;8(1):57-65

Age-associated decline in ascorbic acid concentration, recycling and biosynthesis in rat hepatocytes-reversal with (R)-alpha-lipoic acid supplementation. Lykkesfeldt, J. Hagen, T.M., FASEB J. 12, 1183-1189(year 1998)

Neuroprotection by the Metabolic Antioxidant Alpha Lipoic Acid; Packer, L; Tritschler, H.J, Free Rad Biol Med 22, Nos 1 / 2, 359-378 (1997)

Enantioselective pharmacokinetics and bioavailability of different racemic alpha lipoic acid formulations in healthy volunteers. Hermann, R, Niebch, G, Eur J Pharm Sci 4: 167-174 (1996)  

Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia. Wolz P, Krieglstein J. Neuropharmacology. 1996 Mar;35(3):369-75.

Dose/response curves of lipoic acid R-and S-forms in the working rat heart during reoxygenation: superiority of the R-enantiomer in enhancement of aortic flow. Zimmer G, Beikler TK, Schneider M, et al. Mol Cell Cardiol. 1995 Sep;27(9):1895-903.

See Tory Hagen, Ph.D for links to several articles he has written regarding R-Lipoic Acid.