PBN Cosmetic Applications

The Standard Nitrone Spin Trap for Cosmetic Applications

Profile

PBN (N-tert-butyl-alpha-phenylnitrone) is the established nitrone "spin trap". The term "spin trap" is derived from the technique used to detect and identify free radicals, electron spin resonance. Reactive free radicals are attracted and bound to the beta carbon atom in the spin trap, forming a spin adduct and effectively "trapping" the free radical, allowing the structure of the trapped radical to be deduced.

Spin traps are exceptional molecules that can trap and detoxify damaging free radicals which age the skin. PBN blocks and detoxifies harmful free radical molecules from damaging cells and reduces overall systemic inflammation - the culprit recently discovered to underlie all the degenerative diseases of aging.

PBN has been shown to be an excellent neuroprotective and anti-inflammatory agent and transforms skin damaging free radicals into productive regenerative activity.

Cosmetic Applications and Benefits of PBN Powder

• PBN can provide unique protection against free radical induced skin damage.
• PBN can be administered topically to control inflammatory processes; an underlying cause of skin aging.
• PBN is useful for enhancing the activities of topically applied antioxidants such vitamin C, vitamin E and Lipoic Acid and is commonly incorporated into preparations which include other antioxidants.
• Spin Traps show promise as blocking agents for inflammation caused by UV exposure. Unlike traditional sunscreens, which prevent UV mediated inflammation when used before exposure, spin trap compounds scavenge free radicals and minimize the inflammatory response during and for up to 12 hours after exposure to UV light. By interfering with the inflammatory cascade, these compounds may prevent collagen and elastin degradation, and thus premature aging of the skin.

Specifications

PBN powder for cosmetic application is doubly recrystalised from high purity solvents and is greater than 98% pure (HPLC). PBN is a white crystalline solid; melting point 73°-74° C. PBN powder is poorly soluble in water, but soluble in alcohols. PBN powder is hydrolyzed at low pH into benzaldehyde and N-tert-butyl-hydroxylamine.

Dr. Denham Harman, the father of the "Free Radical Theory of Aging", and keynote speaker at the 2nd Annual Anti-aging Conference in Monaco, referred to PBN and spin traps as a "breakthrough in anti-aging therapy with the potential to significantly slow down the aging process."

In his bestselling book, The Wrinkle Cure, Dr. Nicholas Perricone notes that spin traps are capable of "Stopping Free-Radical Damage Before it Begins..." and that such agents 'create a barrier - a trap - that holds free radicals in place' so that they can be "stopped before they scar the cells that make up your skin." He also claims that researchers "found that the traps actually prevented the free radicals from moving from place to place and damaging cells... and that 'the odds are these free-radical fighters will become a highly effective method of maintaining a youthful, radiant complexion throughout life... Thanks to a spin trap, we will make quantum leaps in the effort to control the effects of aging..."

Packaging

PBN is available in gram to multi-kilogram packaging for the cosmetic industry.