Derick Han, Ph.D.

Derick Han - Curriculum Vitae

Assistant Professor of Research 101 HMR, 2011 Zonal Ave
USC Research Center for Liver Diseases Los, Angeles, CA 90033
USC Keck School of Medicine (626) 643-0864, derickh@usc.edu

Education

  • University of California, Berkeley, BA - Sociology & Biochemistry 1987-1992
  • University of Southern California, PhD - Molecular Pharmacology & Toxicology 1997-2001

Research Experience

  • 1989-1993 Undergraduate researcher - Department of Molecular & Cell Biology at UC Berkeley – Dr. Lester Packer’s laboratory
  • 1993-1997 Staff research associate – Department of Molecular & Cell Biology at UC Berkeley
  • 1997-2001 Graduate student researcher – Department of Molecular Pharmacology & Toxicology at the USC School of Pharmacy
  • 2002-2006 Post-doctoral researcher – USC Research Center for Liver Diseases at the USC Keck School of Medicine
  • 2006-present Assistant professor of research – USC Research Center for Liver Diseases at the USC Keck School of Medicine

Teaching Experience

  • Tutor/Counselor - Consensus Head Injury Clinic – Berkeley, CA (1992-1995)
  • Teaching assistant - Physiology of Aging – upper division undergraduate course at the Department of Molecular Cell Biology at UC Berkeley (1993-1997)
  • Biochemistry and Biological Systems – pharmacy doctorate courses at the USC School of Pharmacy (1997-1999)
  • Lecturer/Instructor - Molecular Pharmacology and Toxicology and Mechanisms of Cell Signaling graduate courses at the USC School of Pharmacy (2004-present)
  • Biochemical and Molecular Sites of Drug Action – pharmacy doctorate course at the USC School of Pharmacy (2004-present)

Societies and Journals

  • Chemico-Biological Interactions – Editorial Board Member (2006 – present)
  • Oxygen Club of California – Secretary General (2004 – present)
  • Society for Free Radical Biology and Medicine

Honors and Awards

  • 2 Young Investigator Awards - Annual meeting of the Oxygen Society (in 1996 and 2000)
  • Presidential Fellow - USC Leadership Institute (2000)
  • Rho Chi Society – Pharmaceutical Honor Society (2001)
  • Pilot project research award - USC Research Center for Liver Research – (2004-2005)
  • Wright Foundation Research Grant – Wright Foundation (July 2006-July 2008)Zumberge Research and Innovation Award – USC
  • Provost for Research Advancement (July 2008 -)

Publications

Research Publications

  1. Kaplowitz N, Shinohara M, Liu ZX, and D Han. How to protect against acetaminophen: don’t ask for JUNK. Gastroenterology (in press).
  2. Saberi B, Hanawa N, Shinohara M, Gaarde W, Kaplowitz, N, and D Han. Regulation of H2O2-induced necrosis byProtein Kinase C and AMP-activated kinase signaling in primary cultured hepatocytes. American Journal ofPhysiology: Cell Physiology (2008) 295: C50-63.
  3. Hanawa N, Shinohara M, Saberi B, Gaarde W, D Han, and N Kaplowitz. Role of JNK translocation to mitochondrialeading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. Journal of BiologicalChemistry (2008) 283: 13565-77.
  4. Zhou Q, Lam PY, Han D, and E Cadenas. c-Jun N-terminal kinase (JNK) regulates mitochondrial bioenergetics bymodulating pyruvate dehydrogenase activity in primary cortical neurons. Journal of Neurochemistry (2008) 104: 325-335.
  5. Inarrea P, Moini H, Han D, Rettori D, Aguilo I, Alava MA, Iturralde M, and E Cadenas. Mitochondrial respiratorychain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications formitochondrial energy metabolism and apoptosis. Biochemical Journal (2007) 405: 173-9.
  6. Han D, Hanawa N, Saberi B, and N Kaplowitz. Hydrogen peroxide and redox modulation sensitize to TNF-inducedapoptosis of primary mouse hepatocytes. Free Radical Biology and Medicine (2006) 41: 627-39.
  7. Liu ZX, Han D, Gunawan B, and N Kaplowitz. Neutrophil depletion protects against murine acetaminophenhepatotoxicity. Hepatology (2006) 43: 1220-30.
  8. Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, and N Kaplowitz. C-Jun N-terminal kinase plays a major rolein murine acetaminophen hepatotoxicity. Gastroenterology (2006) 131: 165-78.
  9. Han D, Hanawa N, Saberi B, and N Kaplowitz. Role of glutathione redox status in liver injury. American Journal ofPhysiology (2006) 291: G1-7.
  10. Han D, Canali R, Garcia J, Aguilera R, Gallaher TK and E Cadenas. Sites and mechanisms of aconitase inactivationby peroxynitrite: modulation by citrate and glutathione. Biochemistry (2005) 44: 11986-96.
  11. Inarrea P, Moini H, Rettori D, Han D, Martinez J, Garcia I, Fernandez-vizarra E, Iturralde M, and E Cadenas. Redoxactivation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase. Biochemical Journal (2005) 387:203-9.
  12. Remiao F, Rettori D, Han D, Carvalho F, Bastos ML, and E Cadenas. Leucoisoprenochrome-o-semiquinoneformation in freshly isoalted adult rat cardiomyocytes. Chemical Research in Toxicology (2005) 17: 1584-90.
  13. Han D, Matsumaru K, Rettori D, and N Kaplowitz. Usnic acid induced necrosis of cultured mouse hepatocytes:inhibition of mitochondrial function and oxidative stress. Biochemical Pharmacology (2004) 67: 439-457.
  14. Remiao F, Rettori D, Han D, Carvalho F, Bastos ML, and E Cadenas. Leucoisoprenochrome-o-semiquinoneformation in freshly isolated adult cardiomyocytes. Chemical Research Toxicology (2004) 17: 1584-90.
  15. Han D, Canali R, Rettori D, and N Kaplowitz. Effect of glutathione depletion on sites and topology of superoxide andhydrogen peroxide in mitochondria. Molecular Pharmacology (2003) 64: 1136-1144.
  16. Han D, Antunes F, Canali R, Rettori D, and E Cadenas. Voltage dependent anion channels control the release ofsuperoxide from mitochondria to the cytosol. Journal of Biological Chemistry (2003) 278: 5557-5563.
  17. Antunes F, Han D, and E Cadenas. Relative contribution of heart mitochondria glutathione peroxidase and catalaseto hydrogen peroxide detoxification in in vivo conditions. Free Radical Biology and Medicine (2002) 33: 1260-1267.
  18. Antunes F, Han D, Rettori D, and E Cadenas. Mitochondrial damage by nitric oxide is potentiated by dopamine inPC12 cells. Biochimica et Biophysica Acta (2002) 1556: 233-38.
  19. Han D, Antunes F, Daneri F, and E Cadenas. Mitochondrial superoxide anion production and release intointermembrane space. Methods in Enzymology (2002) 349: 271-80.
  20. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, and VD Longo. Peroxynitrite mediates neurotoxicity ofamyloid beta-peptide 1-42- and lipopolysaccharide-activated microglia. Journal of Neuroscience (2002) 22: 3484-92.
  21. Han D, Williams E, and E Cadenas. Respiratory chain-dependent generation of superoxide anion towards themitochondrial intermembrane space. Biochemical Journal (2001) 353: 411-416
  22. Kobayashi M, Han D, and L Packer. Antioxidant and herbal extracts protect HT-4 neuronal cells against glutamateinducedcytotoxicity. Free Radical Research (2000) 32: 115-24.
  23. Sokol RJ, McKim JM, Goff MC, Ruyle SZ, Devereaux MW, Han D, Packer L, and G Everson. Vitamin E reducesoxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat. Gastroenterology(1998) 114:164-74.
  24. Lopez-Torres M, Thiele JJ, Shindo Y, Han D, and L Packer. Topical application of a-tocopherol modulates theantioxidant network and diminishes ultraviolet-induced oxidative damage in murine skin. British Journal ofDermatology (1998) 138: 207-15
  25. Han D, Sen CK, Roy S, Kobayashi M, and L Packer. Protection against glutamate-induced cytotoxicty in C6 glialcells by thiol antioxidants. American Journal of Physiology (1997) 273:R1771-78
  26. Han D, Handelman GJ, Marcocci L, Sen CK, Roy S, Kobuchi H, Tritschler HJ, Flohe L, and L Packer. Lipoic acidincreases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors (1997) 6:321-38.
  27. Reznick AZ, Han D, and L Packer. Cigarette smoke induced oxidation of human plasma proteins, lipids, andantioxidants; selective protection by the biothiols dihydrolipoic acid and glutathione. Redox Report (1997) 3: 169-174.
  28. Sen CK, Roy S, Han D, and L Packer. Regulation of Cellular Thiols in Human Lymphocytes by a-Lipoic Acid: A FlowCytometric Analysis. Free Radical Biology and Medicine (1997) 22: 1241-57.
  29. Haramaki N, Han D, Handelman GJ, Tritschler HJ, and L Packer. Cytosolic and mitochondrial systems for NADHandNADPH-dependent Reduction of alpha-lipoic acid. Free Radical Biology and Medicine (1996) 22: 535-42.
  30. Matsugo S, Yan LJ, Han D, Trischler HJ, and L Packer. Decomposition of alpha-lipoic acid derivatives byphotoirradiation-formation of dihydrolipoic acid from alpha-lipoic acid. Biochem Mol Biol Int (1996) 38:51-9.
  31. Han D, Handelman GJ, and L Packer. Analysis of reduced and oxidized lipoic acid in biological samples by highperformanceliquid chromatography. Methods in Enzymology (1995) 251:315-25.
  32. Han D, Tritschler HJ, and L Packer. Alpha-lipoic acid increases intracellular glutathione in a human T-lymphocyteJurkat cell line. Biochemical and Biophysical Research Communications (1995) 207:258-64.
  33. Constantinescu A, Pick U, Handelman GJ, Haramaki N, Han D, Podda M, Tritschler HJ, and L Packer. Reductionand transport of lipoic acid by human erythrocytes. Biochemical Pharmacology (1995) 50:253-61.
  34. Matsugo S, Yan LJ, Han D, Trischler HJ, and L Packer. Elucidation of antioxidant activity of alpha-lipoic acid towardhydroxyl radical. Biochemical and Biophysical Research Communications (1995) 208:161-7.
  35. Matsugo S, Yan LJ, Han D, and L Packer. Induction of protein oxidation in human low density lipoprotein by thephotosensitive organic hydroperoxide, N,N'-bis(2-hydroxyperoxy-2-methoxyethyl)-1,4,5,8-naphthalene-tetracarboxylic-dimide. Biochemical and Biophysical Research Communications (1995) 206:138-45.
  36. Matsugo S, Yan LJ, Han D, Trischler HJ, and L Packer. Elucidation of antioxidant activity of dihydrolipoic acid towardhydroxyl radical using a novel hydroxyl radical generator NP-III. Biochem Mol Biol Int (1995) 37:375-83.
  37. Shindo Y, Witt E, Han D, Epstein W, and L Packer. Enzymatic and non-enzymatic antioxidants in epidermis anddermis of human skin. Journal of Investigative Dermatology (1994) 102:122-4.
  38. Shindo Y, Witt E, Han D, Tzeng B, Aziz T, Nguyen L, and L Packer. Recovery of antioxidants and reduction in lipidhydroperoxides in murine epidermis and dermis after acute ultraviolet radiation exposure. Photodermatology,Photoimmunology and Photomedicine (1994) 10:183-91.
  39. Shindo Y, Witt E, Han D, and L Packer. Dose-response effects of acute ultraviolet irradiation on antioxidants andmolecular markers of oxidation in murine epidermis and dermis. Journal of Investigative Dermatology (1994)102:470-5.
  40. Handelman GJ, Han D, Tritschler H, and L Packer. Alpha-lipoic acid reduction by mammalian cells to the dithiolform, and release into the culture medium. Biochemical Pharmacology (1994) 47:1725-30.
  41. Constantinescu A, Han D, and L Packer. Vitamin E recycling in human erythrocyte membranes. Journal of BiologicalChemistry (1993) 268:10906-13.
  42. Serbinova E, Kagan V, Han D, and L Packer. Free radical recycling and intramembrane mobility in the antioxidantproperties of alpha-tocopherol and alpha-tocotrienol. Free Radical Biology and Medicine (1991) 10:263-75.

Book Chapters

  1. Yap LP, Chang AHK, Han D, and E Cadenas. Free radical biology, mitochondrial functions, and nitric oxide. In Free Radicals in Ophthalmic Disorders. Zierhut M, Cadenas E, and NA Rao ed., Informa healthcare: New York (2008) 1-10.
  2. Han D, Hamilton R, Lam PY, and L Packer. Modulation of cellular redox and metabolic status by lipoic acid. In Alpha Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. Patel M., and L. Packer eds., Taylor and Francis Group: Boca Ranton(year 2008) 293-314.
  3. Yap, LP, Han D, and E Cadenas. Mitochondrial generation of reactive oxygen and nitrogen species and redox signaling. In Search on Glaucoma. C Erb ed., Publiziert von Excerpta Medica: Amsterdam (2007) 4-15.
  4. Han D, Kobayashi M, Cadenas E, and L Packer. Oxidative stress in glutamate neurotoxicity. In Free Radicals in Brain Pathophysiology. Poli G., Cadenas, E., and L. Packer eds., Marcel Dekker: New York(year 2000) 127-51.
  5. Han D, Loukianoff S, and L McLaughlin. Oxidative stress indices: analytical aspects and significance. In Handbook of Oxidants and Antioxidants in Exercise. Sen C.K., Packer, L., and O. Hanninen eds., Elsevier: New York(year 2000) 433-84.
  6. Serbinova E, Kagan V, Han D, and L Packer. d-Alpha-tocotrienol is a more powerful membrane antioxidant than d-Alpha-tocopherol. In Oxidative Damage & Repair: Chemical, Biological, and Medical Aspects. K.J.A. Davies ed., Pergamon Press: New York(year 1991) 77-81
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